The phrase, "when the transgressors have reached their fullness" reminds us that the fulfillment of these prophecies will not occur until man's sinful rebellion reaches the breaking point.
There is a final point where the Lord draws the line and He will not allow man to go any farther without receiving the judgment of God.
Genesis 6:3, "My Spirit shall not strive with man forever."
Mankind's final appointment with destiny is quickly coming to pass!