The first prediction about the antichrist is in Genesis 3:15, "And I will put enmity between thee and the woman, and between thy seed and her seed; He shall bruise thy head, and thou shalt bruise His heel."

       This verse reveals the future conflict between the antichrist, the seed of satan and Jesus, her seed.

            And we also find the first promise of the virgin birth of Jesus in the expression "her seed"; not the natural seed of a father.