"For that Day will not come unless the falling away comes first, and the man of sin is revealed, the son of perdition,"
2 Thessalonians 2:3

The Antichrist is called the 'son of perdition' because he, as the seed of Satan, is destined to destroy and to be destroyed by God.

He will be sent to perdition in hell, because of his sinful rebellion.

Paul called the Antichrist the 'son of perdition' in contrast to Jesus as the 'Son of God'.